Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells.

@article{Coudert2005AlteredNF,
  title={Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells.},
  author={Jerome D Coudert and Jacques Zimmer and Elena Tomasello and Marek Cebecauer and Marco Colonna and Eric Vivier and Werner Held},
  journal={Blood},
  year={2005},
  volume={106 5},
  pages={
          1711-7
        }
}
NKG2D is an activation receptor that allows natural killer (NK) cells to detect diseased host cells. The engagement of NKG2D with corresponding ligand results in surface modulation of the receptor and reduced function upon subsequent receptor engagement. However, it is not clear whether in addition to modulation the NKG2D receptor complex and/or its signaling capacity is preserved. We show here that the prolonged encounter with tumor cell-bound, but not soluble, ligand can completely uncouple… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 115 CITATIONS, ESTIMATED 55% COVERAGE

Regulation of NKG2D Expression and Signaling by Endocytosis.

  • Trends in immunology
  • 2016
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The role of the NKG2D receptor for tumor immunity.

  • Seminars in cancer biology
  • 2006
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis

  • International journal of molecular sciences
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 12 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Comparative analysis of human NK cell activation induced by NKG2D and natural cytototxicity receptors

P André, R Castricioni, +13 authors P. Paul
  • Eur. J. Immunol
  • 2004