Altered NGF response but not release in the aged septo-hippocampal cholinergic system.

@article{Williams2005AlteredNR,
  title={Altered NGF response but not release in the aged septo-hippocampal cholinergic system.},
  author={Brice J. Williams and Matthew J Nelson and A. -Ch. Granholm and Steve Coultrap and Michael Browning and Maria Curtis},
  journal={Experimental neurology},
  year={2005},
  volume={196 1},
  pages={30-40}
}
An important aspect of aging and Alzheimer's disease (AD) pathology includes the degeneration of basal forebrain cholinergic neurons (BFCNs), possibly due to disrupted nerve growth factor (NGF) signaling. Previous studies on disrupted NGF signaling have focused on changes in retrograde transport. This study focuses on two other possible mechanisms for loss of trophic support: diminished release of NGF from hippocampal neurons or diminished TrkA receptor response of BFCNs to NGF. We measured NGF… CONTINUE READING

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