Altered N-glycosylation modulates TgrB1- and TgrC1-mediated development but not allorecognition in Dictyostelium.

@article{Li2015AlteredNM,
  title={Altered N-glycosylation modulates TgrB1- and TgrC1-mediated development but not allorecognition in Dictyostelium.},
  author={Cheng-Lin Frank Li and Gong Bei Chen and Amanda Nicole Webb and Gad Shaulsky},
  journal={Journal of cell science},
  year={2015},
  volume={128 21},
  pages={
          3990-6
        }
}
Cell surface adhesion receptors play diverse functions in multicellular development. In Dictyostelium, two immunoglobulin-like adhesion proteins, TgrB1 and TgrC1, are essential components with dual roles in morphogenesis and allorecognition during development. TgrB1 and TgrC1 form a heterophilic adhesion complex during cell contact and mediate intercellular communication. The underlying signaling pathways, however, have not been characterized. Here, we report on a mutation that suppresses the… CONTINUE READING

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