Altered Motivation and Learning Following Opiate Withdrawal: Evidence for Prolonged Dysregulation of Reward Processing

Abstract

Opiate abuse has been associated with cognitive deficits in human addicts. To determine if prior opiate exposure alters the ability to learn, we trained animals in an instrumental learning task for a food reward. During a 2-week period after withdrawal, morphine-abstinent rats were significantly slower at learning an escalating fixed-ratio response for food… (More)
DOI: 10.1038/sj.npp.1300122

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