Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis

@article{Valli2011AlteredMT,
  title={Altered Medial Temporal Activation Related to Local Glutamate Levels in Subjects with Prodromal Signs of Psychosis},
  author={Isabel Valli and James Stone and Andrea Mechelli and Sagnik Bhattacharyya and Philip Mcguire},
  journal={Biological Psychiatry},
  year={2011},
  volume={69},
  pages={97-99}
}
BACKGROUND Both medial temporal cortical dysfunction and perturbed glutamatergic neurotransmission are regarded as fundamental pathophysiological features of psychosis. However, although animal models of psychosis suggest that these two abnormalities are interrelated, their relationship in humans has yet to be investigated. METHODS We used a combination of functional magnetic resonance imaging and magnetic resonance spectroscopy to investigate the relationship between medial temporal… CONTINUE READING
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