Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy.

@article{Booth2016AlteredIP,
  title={Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy.},
  author={Clair A Booth and Jonathan Witton and Jakub Nowacki and Krasimira Tsaneva-Atanasova and Matthew W. Jones and Andrew D Randall and Jonathan T Brown},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 2},
  pages={350-63}
}
UNLABELLED The formation and deposition of tau protein aggregates is proposed to contribute to cognitive impairments in dementia by disrupting neuronal function in brain regions, including the hippocampus. We used a battery of in vivo and in vitro electrophysiological recordings in the rTg4510 transgenic mouse model, which overexpresses a mutant form of human tau protein, to investigate the effects of tau pathology on hippocampal neuronal function in area CA1 of 7- to 8-month-old mice, an age… CONTINUE READING
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