Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder

@article{Yoon2001AlteredIG,
  title={Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder},
  author={I-S Yoon and Peter Ping Li and K-P Siu and James L Kennedy and Robert G. Cooke and Sandeep S. Kumar and Jerry J. Warsh},
  journal={Molecular Psychiatry},
  year={2001},
  volume={6},
  pages={678-683}
}
Reduced inositol monophosphatase (IMPase) activity and elevated basal intracellular calcium levels ([Ca2+]B) have been reported in B lymphoblast cell lines (BLCLs) from bipolar I affective disorder (BD-I) patients, which may reflect cellular endophenotypes of this disorder. As the PI cycle couples to intracellular Ca2+ mobilization, these two putative endophenotypes may be related. Using an RT-PCR assay, mRNA levels were estimated for IMPA1 and 2 genes encoding human IMPase 1 and 2… CONTINUE READING
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