Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

@article{Peleg2010AlteredHA,
  title={Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice},
  author={Shahaf Yaron Peleg and Farahnaz Sananbenesi and Athanasios Zovoilis and Susanne Burkhardt and Sanaz Bahari-Javan and Roberto Carlos Ag{\'i}s-Balboa and Perla Cota and Jessica L. Wittnam and Andreas Gogol-Doering and Lennart Opitz and Gabriella Salinas-Riester and Markus Dettenhofer and Hui Kang and Laurent Farinelli and Wei Chen and Andr{\'e} Fischer},
  journal={Science},
  year={2010},
  volume={328},
  pages={753 - 756}
}
Age-Old Problem With the increase in human life span, there is an associated increase in incidence of age-associated cognitive decline, which causes a huge emotional and economic burden. However, the mechanisms underlying age-associated memory impairment are poorly understood. Now, Peleg et al. (p. 753; see the Perspective by Sweatt) have found that the memory disturbances in the aging mouse brain are associated with specific changes in learning-induced histone acetylation, which interferes… 
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