Altered Gut Microbiota Promotes Colitis-Associated Cancer in IL-1 Receptor–Associated Kinase M–Deficient Mice

@article{Klimeov2013AlteredGM,
  title={Altered Gut Microbiota Promotes Colitis-Associated Cancer in IL-1 Receptor–Associated Kinase M–Deficient Mice},
  author={K. Klime{\vs}ov{\'a} and M. Kverka and Z. Z{\'a}kostelsk{\'a} and T. Hudcovic and T. Hrncir and R. {\vS}těp{\'a}nkov{\'a} and P. Rossmann and J. R{\'i}dl and M. Kostov{\vc}{\'i}k and J. Mr{\'a}zek and J. Kope{\vc}n{\'y} and Koichi S Kobayashi and H. Tlaskalova-Hogenova},
  journal={Inflammatory Bowel Diseases},
  year={2013},
  volume={19},
  pages={1266–1277}
}
Background:Microbial sensing by Toll-like receptors (TLR) and its negative regulation have an important role in the pathogenesis of inflammation-related cancer. In this study, we investigated the role of negative regulation of Toll-like receptors signaling and gut microbiota in the development of colitis-associated cancer in mouse model. Methods:Colitis-associated cancer was induced by azoxymethane and dextran sodium sulfate in wild-type and in interleukin-1 receptor–associated kinase M (IRAK-M… Expand
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