Altered GalNAc-alpha-2,6-sialylation compartments for mucin-associated sialyl-Tn antigen in colorectal adenoma and adenocarcinoma.

@article{Wang2001AlteredGC,
  title={Altered GalNAc-alpha-2,6-sialylation compartments for mucin-associated sialyl-Tn antigen in colorectal adenoma and adenocarcinoma.},
  author={Fengsong Wang and Marie Goto and Young Ju Kim and Morihiro Higashi and Kohzo Imai and Eiji Sato and Sumiko Yonezawa},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2001},
  volume={49 12},
  pages={1581-92}
}
Sialyl-Tn (STn), a mucin-associated disaccharide antigen carried by apomucins such as MUC2, plays an important role in tumor biology. However, little is known about the subcellular localization and compartments involved in STn synthesis. In this study we used immunoelectron microscopy to localize STn and MUC2 apomucin in human colorectal tissues. MUC2… CONTINUE READING