Altered Function of Ventral Striatum during Reward-Based Decision Making in Old Age

  title={Altered Function of Ventral Striatum during Reward-Based Decision Making in Old Age},
  author={Thomas Mell and Isabell Wartenburger and A. Marschner and Arno Villringer and Friedel Martin Reischies and Hauke R. Heekeren},
  booktitle={Front. Hum. Neurosci.},
Normal aging is associated with a decline in different cognitive domains and local structural atrophy as well as decreases in dopamine concentration and receptor density. To date, it is largely unknown how these reductions in dopaminergic neurotransmission affect human brain regions responsible for reward-based decision making in older adults. Using a learning criterion in a probabilistic object reversal task, we found a learning stage by age interaction in the dorsolateral prefrontal cortex… CONTINUE READING

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