Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?

@article{Creusot2018AlteredFO,
  title={Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?},
  author={R{\'e}mi J Creusot and Jorge Postigo-Fernandez and Nato Teteloshvili},
  journal={Diabetes},
  year={2018},
  volume={67 8},
  pages={
          1481-1494
        }
}
Type 1 diabetes (T1D) arises from a failure to maintain tolerance to specific β-cell antigens. Antigen-specific immunotherapy (ASIT) aims to reestablish immune tolerance through the supply of pertinent antigens to specific cell types or environments that are suitable for eliciting tolerogenic responses. However, antigen-presenting cells (APCs) in T1D patients and in animal models of T1D are affected by a number of alterations, some due to genetic polymorphism. Combination of these alterations… CONTINUE READING
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