Altered Expression of Insulin Receptor Isoforms in Breast Cancer

@inproceedings{Huang2011AlteredEO,
  title={Altered Expression of Insulin Receptor Isoforms in Breast Cancer},
  author={Jiaqi Huang and Chris Morehouse and Katie Streicher and Brandon W. Higgs and Jin Run Gao and Meggan Czapiga and Anmarie Boutrin and Wei Zhu and P Zachary Brohawn and Yong Ik Chang and Jaye Viner and Theresa M Lavallee and Laura Richman and Bahija Jallal and Yihong Yao},
  booktitle={PloS one},
  year={2011}
}
PURPOSE Insulin-like growth factor (IGF) signaling through human insulin receptor isoform A (IR-A) contributes to tumorigenesis and intrinsic resistance to anti-IGF1R therapy. In the present study, we (a) developed quantitative TaqMan real time-PCR-based assays (qRT-PCR) to measure human insulin receptor isoforms with high specificity, (b) evaluated isoform expression levels in molecularly-defined breast cancer subtypes, and (c) identified the IR-A:IR-B mRNA ratio as a potential biomarker… CONTINUE READING
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