Altered Entrainment to the Day/Night Cycle Attenuates the Daily Rise in Circulating Corticosterone in the Mouse

@inproceedings{Sollars2014AlteredET,
  title={Altered Entrainment to the Day/Night Cycle Attenuates the Daily Rise in Circulating Corticosterone in the Mouse},
  author={Patricia J Sollars and Michael J. Weiser and Andrea E. Kudwa and Jayne R. Bramley and Malcolm D. Ogilvie and Robert L Spencer and Robert J. Handa and Gary E. Pickard},
  booktitle={PloS one},
  year={2014}
}
The suprachiasmatic nucleus (SCN) is a circadian oscillator entrained to the day/night cycle via input from the retina. Serotonin (5-HT) afferents to the SCN modulate retinal signals via activation of 5-HT1B receptors, decreasing responsiveness to light. Consequently, 5-HT1B receptor knockout (KO) mice entrain to the day/night cycle with delayed activity onsets. Since circulating corticosterone levels exhibit a robust daily rhythm peaking around activity onset, we asked whether delayed… CONTINUE READING

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