Altered DNA repair; an early pathogenic pathway in Alzheimer’s disease and obesity

Abstract

Unrepaired DNA double-strand breaks (DSBs) are lethal. The present study compared the extent of DSBs, neuronal apoptosis, and status of two major DSB repair pathways - homologous combinational repair (HR) and nonhomologous end-joining (NHEJ) - in hippocampus of 5–6 month and 16–18 month-old wild-type and APP/PSEN1 mice fed control diet or high fat diet (60… (More)
DOI: 10.1038/s41598-018-23644-4

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