Altered DLPFC–Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia
@article{Schneider2017AlteredDC, title={Altered DLPFC–Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia}, author={Michael Schneider and Henrik Walter and Carolin Moessnang and Axel Sch{\"a}fer and Susanne Erk and Sebastian Mohnke and Lydia Romund and Maria Garbusow and Luanna Dixson and Andreas Heinz and Nina Romanczuk-Seiferth and Andreas Meyer-Lindenberg and Heike Tost}, journal={Schizophrenia Bulletin}, year={2017}, volume={43}, pages={1114–1122} }
Altered connectivity of dorsolateral prefrontal cortex (DLPFC) and hippocampus during working memory is considered an intermediate phenotype for schizophrenia (SCZ), but the relevance for other mental disorders with shared genetic background remains unknown. Here we investigated its presence in unaffected first-degree relatives of patients with bipolar disorder (BD) or major depressive disorder (MDD). Furthermore, we aimed to provide an independent replication of this phenotype in first-degree…
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References
SHOWING 1-10 OF 45 REFERENCES
Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia.
- Psychology, MedicineThe American journal of psychiatry
- 2003
OBJECTIVE
The identification of neurobiological intermediate phenotypes may hasten the search for susceptibility genes in complex psychiatric disorders such as schizophrenia. Earlier family studies…
Hippocampal and Frontolimbic Function as Intermediate Phenotype for Psychosis: Evidence from Healthy Relatives and a Common Risk Variant in CACNA1C
- Psychology, MedicineBiological Psychiatry
- 2014
Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.
- Psychology, BiologyArchives of general psychiatry
- 2011
The selective association with a single-nucleotide polymorphism in ZNF804A suggests that this intermediate phenotype proxies a distinct neural system mechanism related to genetic risk for schizophrenia and the biology of this gene.
Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
- Psychology, BiologyNeuroImage
- 2011
Evidence for abnormal cortical functional connectivity during working memory in schizophrenia.
- Psychology, MedicineThe American journal of psychiatry
- 2001
Pronounced disruptions of distributed cooperative activity in schizophrenia were found and a pattern showing disturbed frontotemporal interactions showed promise as a trait marker and may be useful for future investigations.
Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals
- Biology, PsychologyNeuropsychopharmacology
- 2015
It is demonstrated that healthy homozygous carriers of the rs744373 risk allele exhibit worse high-load working memory performance, larger hippocampal volume and lower functional connectivity between the bilateral hippocampus and the right dorsolateral prefrontal cortex, mirroring clinical evidence of disturbed memory and connectivity in patients.
Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
- Psychology, BiologyNature
- 2010
It is suggested that deficits in functional connectivity observed in patients with schizophrenia may be realized at the single-neuron level and impaired long-range synchrony of neural activity is one consequence of the 22q11.2 deletion.
Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first‐episode psychosis
- Psychology, MedicineHuman brain mapping
- 2009
A failure to deactivate the superior temporal lobe during tasks that engage prefrontal cortex is evident at the onset of schizophrenia and may reflect a disruption of fronto‐temporal connectivity.
Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia.
- Psychology, MedicineJAMA psychiatry
- 2014
Healthy first-degree relatives of schizophrenic patients show altered striatal activation during reward anticipation in a directionality and localization consistent with prior patient findings, providing evidence for a functional neural system mechanism related to familial risk.
Altered Functional Subnetwork During Emotional Face Processing: A Potential Intermediate Phenotype for Schizophrenia.
- Psychology, MedicineJAMA psychiatry
- 2016
The results indicate that altered connectivity in a visual-limbic subnetwork during emotional face processing may be a functional connectomic intermediate phenotype for schizophrenia and the phenotype is reliable, task specific, related to trait anxiety, and associated with manifest illness.