Altered DLPFC–Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia

  title={Altered DLPFC–Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia},
  author={Michael Schneider and Henrik Walter and Carolin Moessnang and Axel Sch{\"a}fer and Susanne Erk and Sebastian Mohnke and Lydia Romund and Maria Garbusow and Luanna Dixson and Andreas Heinz and Nina Romanczuk-Seiferth and Andreas Meyer-Lindenberg and Heike Tost},
  journal={Schizophrenia Bulletin},
Altered connectivity of dorsolateral prefrontal cortex (DLPFC) and hippocampus during working memory is considered an intermediate phenotype for schizophrenia (SCZ), but the relevance for other mental disorders with shared genetic background remains unknown. Here we investigated its presence in unaffected first-degree relatives of patients with bipolar disorder (BD) or major depressive disorder (MDD). Furthermore, we aimed to provide an independent replication of this phenotype in first-degree… 

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