Altered Crossover Distribution and Frequency in Spermatocytes of Infertile Men with Azoospermia

@inproceedings{Ren2016AlteredCD,
  title={Altered Crossover Distribution and Frequency in Spermatocytes of Infertile Men with Azoospermia},
  author={He Ren and Kyle A Ferguson and Gordon Kirkpatrick and Tanya Vinning and Victor Chow and Sai Ma},
  booktitle={PloS one},
  year={2016}
}
During meiosis, homologous chromosomes pair to facilitate the exchange of DNA at crossover sites along the chromosomes. The frequency and distribution of crossover formation are tightly regulated to ensure the proper progression of meiosis. Using immunofluorescence techniques, our group and others have studied the meiotic proteins in spermatocytes of infertile men, showing that this population displays a reduced frequency of crossovers compared to fertile men. An insufficient number of… CONTINUE READING
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