Altered Collagen in Tartrate-Resistant Acid Phosphatase (TRAP)-Deficient Mice: A Role for TRAP in Bone Collagen Metabolism

@article{Roberts2007AlteredCI,
  title={Altered Collagen in Tartrate-Resistant Acid Phosphatase (TRAP)-Deficient Mice: A Role for TRAP in Bone Collagen Metabolism},
  author={Helen Clare Roberts and Lynda Knott and Nicholas C. Avery and Timothy Martin Cox and Martin Evans and Alison R. Hayman},
  journal={Calcified Tissue International},
  year={2007},
  volume={80},
  pages={400-410}
}
Tartrate-resistant acid phosphatase (TRAP) is an iron-containing protein that is highly expressed by osteoclasts, macrophages, and dendritic cells. The enzyme is secreted by osteoclasts during bone resorption, and serum TRAP activity correlates with resorptive activity in disorders of bone metabolism. TRAP is essential for normal skeletal development. In knockout mice lacking TRAP, bone shape and modeling is altered with increased mineral density. Here, we report the effect of TRAP on the… CONTINUE READING
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