Altered Circadian Rhythm and Metabolic Gene Profile in Rats Subjected to Advanced Light Phase Shifts

@inproceedings{Herrero2015AlteredCR,
  title={Altered Circadian Rhythm and Metabolic Gene Profile in Rats Subjected to Advanced Light Phase Shifts},
  author={Laura Herrero and Lorea Valcarcel and Crhistiane Andressa da Silva and Nerea Albert and Antoni D{\'i}ez-Noguera and Trinitat Cambras and Dolors Serra},
  booktitle={PloS one},
  year={2015}
}
The circadian clock regulates metabolic homeostasis and its disruption predisposes to obesity and other metabolic diseases. However, the effect of phase shifts on metabolism is not completely understood. We examined whether alterations in the circadian rhythm caused by phase shifts induce metabolic changes in crucial genes that would predispose to obesity. Three-month-old rats were maintained on a standard diet under lighting conditions with chronic phase shifts consisting of advances, delays… CONTINUE READING
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