Altered Ca<ce:sup loc=post>2+</ce:sup> sparks in aging skeletal and cardiac muscle

@article{Weisleder2008AlteredCL,
  title={Altered Ca<ce:sup loc=post>2+</ce:sup> sparks in aging skeletal and cardiac muscle},
  author={Noah L Weisleder and Jianjie Ma},
  journal={Ageing Research Reviews},
  year={2008},
  volume={7},
  pages={177-188}
}
Ca2+ sparks are the fundamental units that comprise Ca2+-induced Ca2+ release (CICR) in striated muscle cells. In cardiac muscle, spontaneous Ca2+ sparks underlie the rhythmic CICR activity during heart contraction. In skeletal muscle, Ca2+ sparks remain quiescent during the resting state and are activated in a plastic fashion to accommodate various levels of stress. With aging, the plastic Ca2+ spark signal becomes static in skeletal muscle, whereas loss of CICR control leads to leaky Ca2… CONTINUE READING

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