Altered Ca<ce:sup loc=post>2+</ce:sup> sparks in aging skeletal and cardiac muscle

  title={Altered Ca<ce:sup loc=post>2+</ce:sup> sparks in aging skeletal and cardiac muscle},
  author={Noah L Weisleder and Jianjie Ma},
  journal={Ageing Research Reviews},
Ca2+ sparks are the fundamental units that comprise Ca2+-induced Ca2+ release (CICR) in striated muscle cells. In cardiac muscle, spontaneous Ca2+ sparks underlie the rhythmic CICR activity during heart contraction. In skeletal muscle, Ca2+ sparks remain quiescent during the resting state and are activated in a plastic fashion to accommodate various levels of stress. With aging, the plastic Ca2+ spark signal becomes static in skeletal muscle, whereas loss of CICR control leads to leaky Ca2… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Motor unit changes in normal aging: a brief review.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie • 2014


Publications referenced by this paper.
Showing 1-10 of 102 references

linked to increased muscle fatigability in the MG29 null mice

M. B. Cannell, D. J. Crossman, C. Soeller
Cell Res • 2006
View 11 Excerpts
Highly Influenced

Calcium spark properties in ventricular myocytes are altered in aged mice.

American journal of physiology. Heart and circulatory physiology • 2006
View 4 Excerpts
Highly Influenced

dihydropyridine receptors

E. Rios, J. J. Ma, A. Gonzalez
J. Biol. Chem • 1991
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…