Altered CD45 expression and disease.

  title={Altered CD45 expression and disease.},
  author={Elma Tchilian and Peter Beverley},
  journal={Trends in immunology},
  volume={27 3},
CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform expression are associated with autoimmune and infectious diseases, establishing CD45 as an important immunomodulator with a significant influence on disease burden. Here, we discuss… CONTINUE READING


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