Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome

  title={Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome},
  author={Silvano Bertelloni and Giampiero I. Baroncelli and Giovanni Federico and Marco Cappa and Roberto Lala and Giuseppe Saggese},
  journal={Hormone Research in Paediatrics},
  pages={309 - 314}
Androgens have major influences on the regulation of bone mineralization. Because of their unique peripheral metabolism androgens may act on bone via activation of the androgen and/or estrogen receptor. Patients with complete androgen insensitivity syndrome (cAIS) are natural models to assess androgen actions on bone. We studied bone mineral density (BMD) in 10 patients with cAIS (mean age 13.70, range 4.7–19.8 years); 3 patients were studied before gonadectomy; the others were castrated and 6… 

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