Altered B cell signalling in autoimmunity

@article{Rawlings2017AlteredBC,
  title={Altered B cell signalling in autoimmunity},
  author={David J Rawlings and Genita Metzler and Michelle N Wray-Dutra and Shaun W Jackson},
  journal={Nature Reviews Immunology},
  year={2017},
  volume={17},
  pages={421-436}
}
Recent work has provided new insights into how altered B cell-intrinsic signals — through the B cell receptor (BCR) and key co-receptors — function together to promote the pathogenesis of autoimmunity. These combined signals affect B cells at two distinct stages: first, in the selection of the naive repertoire; and second, during extrafollicular or germinal centre activation responses. Thus, dysregulated signalling can lead to both an altered naive BCR repertoire and the generation of… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 62 times over the past 90 days. VIEW TWEETS

5 Figures & Tables

Topics

Statistics

010203020172018
Citations per Year

Citation Velocity: 12

Averaging 12 citations per year over the last 2 years.

Learn more about how we calculate this metric in our FAQ.