Altered B cell signalling in autoimmunity

  title={Altered B cell signalling in autoimmunity},
  author={David J Rawlings and Genita Metzler and Michelle N Wray-Dutra and Shaun W Jackson},
  journal={Nature Reviews Immunology},
Recent work has provided new insights into how altered B cell-intrinsic signals — through the B cell receptor (BCR) and key co-receptors — function together to promote the pathogenesis of autoimmunity. These combined signals affect B cells at two distinct stages: first, in the selection of the naive repertoire; and second, during extrafollicular or germinal centre activation responses. Thus, dysregulated signalling can lead to both an altered naive BCR repertoire and the generation of… CONTINUE READING
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