Altered Absorption of Digoxin, Sustained-Release Quinidine, and Warfarin with Sucralfate Administration

@article{Rey1991AlteredAO,
  title={Altered Absorption of Digoxin, Sustained-Release Quinidine, and Warfarin with Sucralfate Administration},
  author={Aixa Rey and John G. Gums},
  journal={Annals of Pharmacotherapy},
  year={1991},
  volume={25},
  pages={745 - 746}
}
A case is reported of a 71-year-old woman who displayed altered absorption of digoxin, quinidine sulfate, and warfarin sodium after being given sucralfate. The administration of sucralfate resulted in subtherapeutic serum concentrations of digoxin and quinidine, and also reduced the patient's prothrombin time (PT). Discontinuation of sucralfate increased PT and reestablished therapeutic concentrations of digoxin, quinidine, and warfarin. Patients receiving sucralfate concomitantly with digoxin… 
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