Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure

Abstract

AbstractAim:To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure.Methods:Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, KATP channel-mediated relaxation responses in the aortas and mesenteric arteries, KATP channel current, and gene expression were examined, respectively.Results:Blood pressure and body weight were increased in rats fed with high-fat diet. KATP channel-mediated relaxation responses, currents, and KATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats.Conclusion:Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.

DOI: 10.1111/j.1745-7254.2008.00810.x

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Cite this paper

@article{Fan2008AlteredAP, title={Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure}, author={Lihong Fan and Hong-yan Tian and Ai-qun Ma and Zhi Gang Hu and Jian-hua Huo and Yong-Xiao Cao}, journal={Acta Pharmacologica Sinica}, year={2008}, volume={29}, pages={1167-1174} }