Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome.

@article{Atkinson2006Altered5S,
  title={Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome.},
  author={Wendy L. Atkinson and Stephen J Lockhart and Peter J Whorwell and Brian G Keevil and L A Houghton},
  journal={Gastroenterology},
  year={2006},
  volume={130 1},
  pages={34-43}
}
BACKGROUND & AIMS Evidence suggests that postprandial platelet-depleted plasma 5-hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome (IBS). However, interpretation of the data has been hampered by the variable methodology and rather small numbers used in previous studies. Therefore, the aim of this study was to measure concentrations of platelet-depleted plasma 5-HT and its metabolite 5-HIAA under fasting and fed conditions in a large group of patients with… CONTINUE READING