Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

@inproceedings{Kakuda2012AlteredA,
  title={Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease},
  author={Nobuto Kakuda and M Shoji and Hiroyuki Arai and Katsutoshi Furukawa and Takeshi Ikeuchi and Kohei Akazawa and Mako Takami and Hiroyuki Hatsuta and Shigeo Murayama and Yasuhiro Hashimoto and Masakazu Miyajima and Hajime Arai and Yu Nagashima and Haruyasu Yamaguchi and Ryozo Kuwano and Kazuhiro Nagaike and Yasuo Ihara},
  booktitle={EMBO molecular medicine},
  year={2012}
}
We investigated why the cerebrospinal fluid (CSF) concentrations of Aβ42 are lower in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Because Aβ38/42 and Aβ40/43 are distinct product/precursor pairs, these four species in the CSF together should faithfully reflect the status of brain γ-secretase activity, and were quantified by specific enzyme-linked immunosorbent assays in the CSF from controls and MCI/AD patients. Decreases in the levels of the precursors, Aβ42 and 43… CONTINUE READING
14 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Amyloid b 38, 40, and 42 species in cerebrospinal fluid: more of the same

  • NS Schoonenboom, C Mulder, +4 authors PD Mehta
  • Ann Neurol
  • 2005
Highly Influential
1 Excerpt

Potent amyloidogenicity and pathogenicity of Ab43

  • T Saito, T Suemoto, +7 authors J Takano
  • Nat Neurosci
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…