Alterations to the blood-retinal barrier in diabetes: cytokines and reactive oxygen species.

@article{Frey2011AlterationsTT,
  title={Alterations to the blood-retinal barrier in diabetes: cytokines and reactive oxygen species.},
  author={Tiffany Frey and David A Antonetti},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 5},
  pages={1271-84}
}
Diabetic retinopathy (DR) is a leading cause of blindness in Western society. Since the prevalence of diabetes continues to increase dramatically, the impact of DR will only worsen unless new therapeutic options are developed. Recent data demonstrate that oxidative stress contributes to the pathology of DR and inhibition of oxidative stress reduces retinal vascular permeability. However, direct mechanisms by which oxidative stress alters the blood-retinal barrier (BRB) and increases vascular… CONTINUE READING
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