Alterations to proteome and tissue recovery responses in fish liver caused by a short-term combination treatment with cadmium and benzo[a]pyrene.

@article{Costa2010AlterationsTP,
  title={Alterations to proteome and tissue recovery responses in fish liver caused by a short-term combination treatment with cadmium and benzo[a]pyrene.},
  author={Pedro Maur{\'i}cio Costa and Eduardo Chicano-G{\'a}lvez and J L{\'o}pez Barea and T. Angel DelValls and Maria Helena Bueno da Costa},
  journal={Environmental pollution},
  year={2010},
  volume={158 10},
  pages={3338-46}
}
The livers of soles (Solea senegalensis) injected with subacute doses of cadmium (Cd), benzo[a]pyrene (B[a]P), or their combination, were screened for alterations to cytosolic protein expression patterns, complemented by cytological and histological analyses. Cadmium and B[a]P, but not combined, induced hepatocyte apoptosis and Kupfer cell hyperplasia. Proteomics, however, suggested that apoptosis was triggered through distinct pathways. Cadmium and B[a]P caused upregulation of different anti… CONTINUE READING

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