Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor.

@article{Gadelha2019AlterationsOG,
  title={Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor.},
  author={Ana Paula Rocha Gadelha and B{\'a}rbara de Gaspar Bravim and Juliana C Vidal and Lissa Catherine Reignault and Bruno Cosme and Kilian V. M. Huber and Franz Bracher and Wanderley de Souza},
  journal={International journal of medical microbiology : IJMM},
  year={2019},
  volume={309 2},
  pages={
          130-142
        }
}
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8 Citations

8 Citations

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Salvage strategies including various options for combination therapy exist in spite of limited evidence and lacking routine diagnostic-compatible assays for antimicrobial susceptibility testing in G. duodenalis.
Nanoarchitecture of the ventral disc of Giardia intestinalis as revealed by high-resolution scanning electron microscopy and helium ion microscopy
TLDR
Results showed that the disc is a non-uniformly organized structure that presents specific domains, such as the margin and the ventral groove region, and actin-like filaments and microtubules of the disc are associated, showing an interconnection between elements of the cytoskeleton of the trophozoite.
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TLDR
This compound produced morphologic modifications of trophozoites, with occasional loss of one of the nuclei, among other changes not observed with standard giardicidal drugs, suggesting that it might act through a novel mechanism of action.
Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations.
In vitro effects of the 4-[(10H-phenothiazin-10-yl)methyl]-N-hydroxybenzamide on Giardia intestinalis trophozoites.

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