Alterations on Na+,K+-ATPase and Acetylcholinesterase Activities Induced by Amyloid-β Peptide in Rat Brain and GM1 Ganglioside Neuroprotective Action

@article{Kreutz2013AlterationsON,
  title={Alterations on Na+,K+-ATPase and Acetylcholinesterase Activities Induced by Amyloid-β Peptide in Rat Brain and GM1 Ganglioside Neuroprotective Action},
  author={Fernando Kreutz and Emilene Barros da Silva Scherer and Andr{\'e}a G. K. Ferreira and Fernanda dos Santos Petry and Camila Lino Pereira and Fabiana Santana and Angela Terezinha de Souza Wyse and Christianne Gazzana Salbego and Vera Maria Treis Trindade},
  journal={Neurochemical Research},
  year={2013},
  volume={38},
  pages={2342-2350}
}
Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathogenesis involves production and aggregation of amyloid-β peptide (Aβ). Aβ-induced toxicity is believed to involve alterations on as Na+,K+-ATPase and acetylcholinesterase (AChE) activities, prior to neuronal death. Drugs able to prevent or to reverse these biochemical changes promote neuroprotection. GM1 is a ganglioside proposed to have neuroprotective roles in AD models, through mechanisms not yet fully understood. Therefore… CONTINUE READING

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