Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid.

@article{Buja1985AlterationsOU,
  title={Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid.},
  author={Luis Maximilian Buja and Herbert K. Hagler and D. Parsons and Kenneth R. Chien and Robert C. Reynolds and James T. Willerson},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1985},
  volume={53 4},
  pages={397-412}
}
The purpose of this study was to document changes in cellular fine structure and elemental composition, and their relationship to progression of cell injury, in cultured neonatal rat cardiac myocytes in which impaired energy metabolism was produced by the metabolic inhibitor, iodoacetic acid (IAA). In order to quantitate changes in the concentrations of elements and their subcellular distribution in individual myocytes, electron probe x-ray microanalysis was performed on freeze-dried… CONTINUE READING

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