Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long-term hypertension in rats.

@article{Kojda1998AlterationsOT,
  title={Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long-term hypertension in rats.},
  author={Georg Kojda and K Kottenberg and A. Hacker and Eva Maria Noack},
  journal={Pharmaceutica acta Helvetiae},
  year={1998},
  volume={73 1},
  pages={27-35}
}
NO as produced by NO-synthases (NOS) contributes to the regulation of cardiovascular functions. In hypertension, there is a reduced production and/or activity of endogenous NO in the vasculature. We investigated if hypertension alters the NO-sensitivity of soluble guanylate cyclase (sGC) in blood vessels and heart muscle isolated from 15 month old… CONTINUE READING