Alterations of the synovial T cell repertoire in anti-citrullinated protein antibody-positive rheumatoid arthritis.

@article{Cantaert2009AlterationsOT,
  title={Alterations of the synovial T cell repertoire in anti-citrullinated protein antibody-positive rheumatoid arthritis.},
  author={Tineke Cantaert and Sophie Brouard and Rogier M. Thurlings and Annaick Pallier and Gabriela Franco Salinas and Christophe Braud and Paul L. Klarenbeek and Niek de Vries and Yiping Zhang and Jean Paul Soulillou and Paul Peter Tak and D. Baeten},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 7},
  pages={1944-56}
}
OBJECTIVE The association of HLA-DRB1 alleles with anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) suggests the potential involvement of T lymphocytes in ACPA-seropositive disease. The purpose of this study was to investigate this hypothesis by systematic histologic and molecular analyses of synovial T cells in ACPA+ versus ACPA- RA patients. METHODS Synovial biopsy samples were obtained from 158 RA patients. Inflammation was determined histologically and… CONTINUE READING