Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction.

Abstract

OBJECTIVE The goal of this study was to investigate alterations of the endogenous opioid system in cardiac hypertrophy, to elucidate mechanisms of preproenkephalin (ppENK) gene expression, and to assess effects of endogenous opioids on myocardial contractility and atrioventricular conduction. METHODS Hypertrophy was induced by ligation of a renal artery… (More)

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