Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.

@article{Morosetti1995AlterationsOT,
  title={Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.},
  author={Roberta Morosetti and Norihiko Kawamata and Adrian F Gombart and Carl W. Miller and Yoshihiro Hatta and Toshiyasu Hirama and Jonathan Said and Masao Tomonaga and H Phillip Koeffler},
  journal={Blood},
  year={1995},
  volume={86 5},
  pages={1924-30}
}
The protein p27KIP1 belongs to a recently identified family of proteins termed cyclin-dependent kinase inhibitors (CDKIs). These proteins play an important role in regulating cell-cycle progression and loss of their function has been implicated in tumorigenesis. Transforming growth factor beta (TGF-beta) may induce cell growth arrest through p27 activation. TGF-beta often loses its ability to arrest growth of transformed cells; this could potentially occur through a defect in p27. To determine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…