Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies.

PURPOSE The p16 (MTS1) gene codes for a cyclin-dependent kinase inhibitor and may be a new tumor suppressor gene. It is frequently mutated in a variety of cell lines established from tumors. This is the first report of screening for alteration of the p16 gene in testicular, ovarian and endometrial malignancies. MATERIALS AND METHODS We examined… CONTINUE READING