Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: Neuronal damage and immunocytochemical changes in chronic epileptic rats

@article{Silva2002AlterationsOT,
  title={Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: Neuronal damage and immunocytochemical changes in chronic epileptic rats},
  author={A. V Silva and Emilio Rafael Garrido Sanabria and Esper Abr{\~a}o Cavalheiro and Roberto Spreafico},
  journal={Brain Research Bulletin},
  year={2002},
  volume={58},
  pages={417-421}
}
A wealth of previous studies reported pathological alterations in extrahippocampal regions in mesial temporal lobe epilepsy. Previous experimental findings have also demonstrated that the entorhinal cortex and the neocortex are damaged in different animal models of acute limbic seizures. The present study was aimed at verifying possible alterations in neocortical areas, and, in particular, structural changes of GABAergic interneurons in the sensorimotor cortex, in pilocarpine-induced chronic… Expand
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