Alterations of the microvascular network in sclerotic hippocampi from patients with epilepsy.

@article{Kastanauskaite2009AlterationsOT,
  title={Alterations of the microvascular network in sclerotic hippocampi from patients with epilepsy.},
  author={Asta Kastanauskaite and Lidia Alonso-Nanclares and Lidia Blazquez-Llorca and Jes{\'u}s Gadea Pastor and Rafael G. Sola and Javier DeFelipe},
  journal={Journal of neuropathology and experimental neurology},
  year={2009},
  volume={68 8},
  pages={
          939-50
        }
}
The main hallmarks of human hippocampal sclerosis are neuronal loss and gliosis; reductions in microvasculature labeling in the cornu Ammonis 1 in this condition have been detected using alkaline phosphatase histochemistry. To determine whether the reduction in alkaline phosphatase activity is coupled with a loss of blood vessels,we examined the volume fraction occupied by blood vessels in toluidine blue-stained hippocampal sections from 24 epilepsy patient resections (19 with hippocampal… CONTINUE READING

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