Alterations of the intestinal transport and processing of gliadin peptides in celiac disease.

@article{MatysiakBudnik2003AlterationsOT,
  title={Alterations of the intestinal transport and processing of gliadin peptides in celiac disease.},
  author={Tamara Matysiak-Budnik and C{\'e}line Candalh and Christophe Dugave and A. Namane and Christophe Cellier and Nadine Cerf-Bensussan and Martine Heyman},
  journal={Gastroenterology},
  year={2003},
  volume={125 3},
  pages={
          696-707
        }
}
BACKGROUND & AIMS The hypothesis of a defect in the intestinal transport and processing of toxic (31-49) or immunostimulant (57-68 and the 33-mer 56-89) gliadin peptides was tested in patients with active celiac disease (ACD), patients with treated celiac disease (TCD), and controls. METHODS Using duodenal biopsy specimens mounted in Ussing chambers, we measured electrical resistance, mucosal-to-serosal radiolabeled-peptide fluxes, and peptide processing during transport using radio-reverse… CONTINUE READING
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