Alterations of the expression of T-cell-related costimulatory CD28 and downregulatory CD152 (CTLA-4) molecules in patients with B-cell chronic lymphocytic leukaemia

@article{Frydecka2004AlterationsOT,
  title={Alterations of the expression of T-cell-related costimulatory CD28 and downregulatory CD152 (CTLA-4) molecules in patients with B-cell chronic lymphocytic leukaemia},
  author={Irena Frydecka and Agata Kosmaczewska and Dorota Bo{\'c}ko and Lidia Ciszak and Dariusz Wolowiec and Kazimierz Kuliczkowski and Iwona Ewa Kochanowska},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={2042 - 2048}
}
In the present study, we have examined the kinetics and magnitude of expression of the CD28 and CD152 molecules on unstimulated and anti-CD3+rIL-2-stimulated peripheral blood CD4+ and CD8+ T cells in patients with chronic lymphocytic leukaemia (B-CLL) and controls. The mean percentages of both CD3+/CD4+/CD28+ and CD3+/CD8+/CD28+ cells were significantly lower in B-CLL than in controls before culture, decreased rapidly, reaching their lowest levels between 24 and 48 h, and returned to basal… CONTINUE READING

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