Alterations of the cyclin D1/p16-pRB pathway in mantle cell lymphoma.

  title={Alterations of the cyclin D1/p16-pRB pathway in mantle cell lymphoma.},
  author={Martin H. Dreyling and Lars Bullinger and German Ott and Stephan Stilgenbauer and Hans-Konrad Mueller-Hermelink and Martin Bentz and Wolfgang Hiddemann and Hartmut D{\"o}hner},
  journal={Cancer research},
  volume={57 20},
Mantle cell lymphoma (MCL) has recently become generally accepted as a subentity of malignant lymphomas that is characterized by the chromosomal translocation t(11;14)(q13;q32), resulting in the overexpression of cyclin D1. Cyclin D1 forms a complex with cell cycle-dependent kinase (cdk) 4, which inactivates the retinoblastoma protein (pRB) via phosphorylation. However, in transgenic mice, the overexpression of cyclin D1 alone is not sufficient for the development of malignant lymphoma. To… CONTINUE READING
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