Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance.

@article{Zhang2007AlterationsOT,
  title={Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance.},
  author={Jinhui Zhang and Wendy G Wright and David A Bernlohr and Samuel W. Cushman and Xiaoli Chen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 5},
  pages={
          E1433-40
        }
}
Adipose tissue inflammation has recently been linked to the pathogenesis of obesity and insulin resistance. C1 complex comprising three distinct proteins, C1q, C1r, and C1s, involves the key initial activation of the classic pathway of complement and plays an important role in the initiation of inflammatory process. In this study, we investigated adipose expression and regulation of C1 complement subcomponents and C1 activation regulator decorin in obesity and insulin resistance. Expression of… CONTINUE READING

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The complement system in human cardiometabolic disease.

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