Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.

@article{Takagi2000AlterationsOT,
  title={Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.},
  author={Yasushi Takagi and Manabu Futamura and Ken Yamaguchi and Shigeo Aoki and Tsuyoshi Takahashi and Shigetoyo Saji},
  journal={Gut},
  year={2000},
  volume={47 2},
  pages={268-71}
}
BACKGROUND/AIMS In 1998 the PPP2R1B gene encoding the A subunit of the serine/threonine protein phosphatase was identified as a putative tumour suppressor gene in lung and colon cancer in the chromosome region 11q22-24. The aim of the present study was to determine the type of alterations in primary rectal cancers as well as colon cancers and the correlation between these alterations and clinicopathological data. METHODS Mutation analyses of the PPP2R1B gene sequence encoding the binding… CONTINUE READING

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