Alterations of the INK4a/ARF locus in human intracranial germ cell tumors.

@article{Iwato2000AlterationsOT,
  title={Alterations of the INK4a/ARF locus in human intracranial germ cell tumors.},
  author={Masayuki Iwato and Osamu Tachibana and Yasuo Tohma and Yasuaki Arakawa and Hidetoshi Nitta and Mitsuhiro Hasegawa and Junkoh Yamashita and Yutaka Hayashi},
  journal={Cancer research},
  year={2000},
  volume={60 8},
  pages={2113-5}
}
Little is known about the molecular mechanisms responsible for the development of intracranial germ cell tumors (ICGTs). Recently, we demonstrated that the balance of the p53-mdm2 interactions is disrupted in ICGTs. The p14ARF product, a tumor suppresser gene located on the INK4a/ARF locus, acts as one of the major factors affecting p53-mdm2 interactions… CONTINUE READING