Alterations of the INK 4 a / ARF Locus in Human Intracranial Germ Cell Tumors 1

@inproceedings{Iwato2000AlterationsOT,
  title={Alterations of the INK 4 a / ARF Locus in Human Intracranial Germ Cell Tumors 1},
  author={Masayuki Iwato and Osamu Tachibana and Yasuo Tohma and Yasuaki Arakawa and Hisashi Nitta and Mitsuhiro Hasegawa and Junkoh Yamashita and Yutaka Hayashi},
  year={2000}
}
Little is known about the molecular mechanisms responsible for the development of intracranial germ cell tumors (ICGTs). Recently, we demonstrated that the balance of the p53-mdm2 interactions is disrupted in ICGTs. The p14 product, a tumor suppresser gene located on the INK4a/ARF locus, acts as one of the major factors affecting p53-mdm2 interactions via… CONTINUE READING