Alterations of the B-cell response by HIV-1 replication.

@article{Shen2011AlterationsOT,
  title={Alterations of the B-cell response by HIV-1 replication.},
  author={Xiaoying Shen and Georgia D. Tomaras},
  journal={Current HIV/AIDS reports},
  year={2011},
  volume={8 1},
  pages={23-30}
}
While the hallmark of HIV-1 infection is the progressive depletion of CD4(+) T cells, extensive B-cell dysfunction ensues that impairs the quality of the humoral response. HIV-1 infection causes hypergammaglobulinemia, polyclonal activation, loss of memory B-cell subsets, B-cell exhaustion, aberrant B-cell surface markers, and impaired humoral responses against infections and vaccinations. The totality of the mechanisms that contribute to B-cell dysfunction in vivo is unknown, although roles… CONTINUE READING

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A better understanding of how HIV-1 subverts a productive B - cell response is needed to inform vaccine strategies that aim to elicit long - lived plasma cells and memory B - cell responses that can act quickly upon antigen stimulation .
A better understanding of how HIV-1 subverts a productive B - cell response is needed to inform vaccine strategies that aim to elicit long - lived plasma cells and memory B - cell responses that can act quickly upon antigen stimulation .
A better understanding of how HIV-1 subverts a productive B - cell response is needed to inform vaccine strategies that aim to elicit long - lived plasma cells and memory B - cell responses that can act quickly upon antigen stimulation .
A better understanding of how HIV-1 subverts a productive B - cell response is needed to inform vaccine strategies that aim to elicit long - lived plasma cells and memory B - cell responses that can act quickly upon antigen stimulation .
A better understanding of how HIV-1 subverts a productive B - cell response is needed to inform vaccine strategies that aim to elicit long - lived plasma cells and memory B - cell responses that can act quickly upon antigen stimulation .
A better understanding of how HIV-1 subverts a productive B - cell response is needed to inform vaccine strategies that aim to elicit long - lived plasma cells and memory B - cell responses that can act quickly upon antigen stimulation .
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