Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging

@article{Yoshida2000AlterationsOT,
  title={Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging},
  author={Yu-Ichi Yoshida and Setsuko Eda and Masahiro Masada},
  journal={Brain and Development},
  year={2000},
  volume={22},
  pages={45-49}
}
In the present study, we investigated age-related changes in pteridine levels and enzymatic activity responsible for tetrahydrobiopterin biosynthesis in mouse tissues. Until about 15 weeks after the birth, the remarkable change of tetrahydrobiopterin (BH4) was observed in all tissues tested. Between 20 and 50 weeks after the birth, pteridines levels were almost constant in all of the tissues. Total biopterin levels were decreased and levels of pterin and neopterin were increased in the period… CONTINUE READING

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