Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

@article{Shimizu2003AlterationsOS,
  title={Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants},
  author={Eiji Shimizu and Kenji Hashimoto and Naoe Okamura and Kaori Koike and Naoya Komatsu and Chikara Kumakiri and Michiko Nakazato and Hiroyuki Watanabe and Naoyuki Shinoda and Sin-ichi Okada and Masaomi Iyo},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={70-75}
}
Decreased Levels of Serum Brain-Derived Neurotrophic Factor in Male Pediatric Patients with Depression
TLDR
Low BDNF levels may play a role in the pathophysiology of male pediatric patients with depression, according to a significant negative correlation between the serum levels of BDNF and the duration of illness in male, but not female, pediatric patientsWith depression.
Plasma Brain-Derived Neurotrophic Factor as a Peripheral Marker for the Action Mechanism of Antidepressants
TLDR
The results suggest that the therapeutic response after antidepressant administration might be attributable to the increase in BDNF levels, which may play a critical role in the action mechanism of antidepressant drugs.
Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode
TLDR
It is suggested that antidepressant treatment has a positive effect on serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders.
Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
TLDR
The hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients is supported.
The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study
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References

SHOWING 1-10 OF 34 REFERENCES
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
TLDR
The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.
Neurotrophins and depression.
  • C. Altar
  • Biology, Psychology
    Trends in pharmacological sciences
  • 1999
Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
TLDR
It is demonstrated that BDNF and NT-3 are stress-responsive genes and the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus is raised.
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