Alterations of respiratory chain complexes in sporadic pheochromocytoma.

  title={Alterations of respiratory chain complexes in sporadic pheochromocytoma.},
  author={Ren{\'e} G Feichtinger and Franz A Zimmermann and Johannes A Mayr and Daniel Neureiter and Manfred Ratschek and Neil P. Jones and Wolfgang Sperl and Barbara Kofler},
  journal={Frontiers in bioscience},
Succinate dehydrogenase (SDH) has been associated with carcinogenesis in hereditary pheochromocytoma (PC) and paraganglioma. We investigated if a similar association applies to sporadic pheochromocytoma. No genetic alteration was found in the SDHB, SDHC or SDHD genes of sporadic PC. However, in eight of nine sporadic PCs the SDH activity was, on average… CONTINUE READING